Translation and Its Regulation in Cancer Biology and Medicine

Translation and Its Regulation in Cancer Biology and Medicine
Author : Armen Parsyan
Publisher : Springer
Total Pages : 697
Release : 2016-08-23
ISBN 10 : 9402403515
ISBN 13 : 9789402403510
Language : EN, FR, DE, ES & NL

This book, for the first time, comprehensively assembles and analyzes a large body of information on the role of the fundamental mechanism of the protein biosynthesis pathway, translation, in cancer biology. It systematically explores the function of the translation machinery and its regulation, including cell signaling, in the development, maintenance and progression of human cancer. The work presented here unveils the tremendous potential and applications of this vast and exciting branch of genetic, biochemical and molecular science in cancer medicine and drug development. Chapters contributed by experts in the field take the reader on a journey that starts with a dissection of the translation machinery and its regulation in norm and cancer. Later chapters characterize etiological and pathogenetic roles that translation plays in specific cancer types. Various aspects of diagnostic, prognostic and therapeutic significance of the translation machinery and its control in cancer are discussed. Readers will discover the importance of the process of translation and its regulatory mechanisms in physiology and cancer biology. The chapters and the numerous illustrations included here were contributed by expert scientists and clinicians from renowned academic and clinical establishments in Canada, the United States of America, the United Kingdom, Italy, France, Belgium, Spain, Germany and Australia. The book conveys information and knowledge that may interest a broad range of students and scholars ranging from basic scientists to clinicians and drug developers seeking to better understand the protein synthesis and its aberrations in cancer biology and cancer medicine.

Translation and Its Regulation in Cancer Biology and Medicine
Language: en
Pages: 697
Authors: Armen Parsyan
Categories: Medical
Type: BOOK - Published: 2016-08-23 - Publisher: Springer

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This book, for the first time, comprehensively assembles and analyzes a large body of information on the role of the fundamental mechanism of the protein biosyn
Translation and Its Regulation in Cancer Biology and Medicine
Language: en
Pages: 697
Authors: Armen Parsyan
Categories: Medical
Type: BOOK - Published: 2014-10-13 - Publisher: Springer

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This book, for the first time, comprehensively assembles and analyzes a large body of information on the role of the fundamental mechanism of the protein biosyn
The Unfolded Protein Response in Cancer
Language: en
Pages: 220
Authors: Robert Clarke
Categories: Medical
Type: BOOK - Published: 2019-03-01 - Publisher: Springer

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This volume presents state-of-the-art information on each of the arms of the unfolded protein response (UPR), how their activation/repression are regulated, int
Transcription and Translation in Health and Disease
Language: en
Pages: 0
Authors: Manoj Garg
Categories: Science
Type: BOOK - Published: 2023-02-01 - Publisher: Academic Press

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Transcription and Translation in Health and Disease provides a detailed overview of the regulators underlying transcription and translation in relation to a var
Emerging Concepts in Ribosome Structure, Biogenesis, and Function
Language: en
Pages: 296
Authors: Vijay Kumar
Categories: Science
Type: BOOK - Published: 2021-09-25 - Publisher: Academic Press

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Ribosome biogenesis is the process of making ribosomes which are responsible for mRNA translation into proteins. It is a tightly regulated process closely linke
Cancer RNome: Nature & Evolution
Language: en
Pages: 313
Authors: Mansi Arora
Categories: Medical
Type: BOOK - Published: 2018-11-02 - Publisher: Springer

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In the last decade, researchers working in the field of cancer biology have shifted their focus from genetic defects to epigenetic dysregulation, especially tha
Tumor Suppressor Genes in Human Cancer
Language: en
Pages: 410
Authors: David E. Fisher
Categories: Medical
Type: BOOK - Published: 2001 - Publisher: Springer Science & Business Media

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This book covers the clinical and experimental observations that led to tumor suppressor gene discovery as well as detailed mechanistic reviews of tumor suppres
Cancer Biology Review
Language: en
Pages: 208
Authors: Walter Stadler, MD
Categories: Medical
Type: BOOK - Published: 2013-08-28 - Publisher: Demos Medical Publishing

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Utilizing the teaching value of real-world case discussions, Cancer Biology Review presents the principles of cancer biology in a clear and memorable manner, al
Redox Signaling and Regulation in Biology and Medicine
Language: en
Pages: 514
Authors: Claus Jacob
Categories: Science
Type: BOOK - Published: 2009-05-06 - Publisher: John Wiley & Sons

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This first entry-level guide to the multifaceted field takes readers one step further than existing textbooks. In an easily accessible manner, the authors integ
mTOR Inhibition for Cancer Therapy: Past, Present and Future
Language: en
Pages: 300
Authors: Monica Mita
Categories: Medical
Type: BOOK - Published: 2015-11-18 - Publisher: Springer

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This book describes the challenges involved in developing mTOR inhibitors for cancer treatment, starting with an in-depth examination of their molecular mechani