Genetics and Epigenetics of Psychiatric Diseases, 2nd Edition

Genetics and Epigenetics of Psychiatric Diseases, 2nd Edition
Author : Cunyou Zhao
Publisher : Frontiers Media SA
Total Pages : 205
Release : 2020-10-09
ISBN 10 : 9782889660254
ISBN 13 : 2889660257
Language : EN, FR, DE, ES & NL

Psychiatric diseases have a highly complex etiology, aggregating in families but not segregating in a traditional Mendelian manner. Recent approaches to understanding the causes of psychiatric disease have focused on describing the genetic contribution to major psychiatric illnesses; the use of large-scale genome-wide association studies (GWAS) and exome sequencing has enabled a systematic exploration of genetic risk factors and identified over 100 independent genomic loci significantly associated with psychiatric diseases; however, there remains uncertainty about the causal genes involved in disease pathogenesis, and how their function is regulated. Since many GWAS variants reside in non-coding regions, the disease-associated common variants might be enriched in regulatory domains, including enhancers and regions of active chromatin state. These lead us to focus on the possible role of non-sequence-based genomic variation in health and disease. Of particular interest are epigenetic modifications that regulate gene expression through modifications to DNA, RNA, histone proteins, and chromatin. The availability of high-throughput profiling methods for quantifiying epigenomic modifications in large numbers of samples has enabled us to perform epigenome-wide association studies (EWAS) aimed at screening methylomic variations associated with environmental exposure and disease. Thus systematic integration of genetic, epigenetic and epidemiological approaches will contribute to improving our understanding of the molecular mechanisms underlying disease phenotypes.

Genetics and Epigenetics of Psychiatric Diseases, 2nd Edition
Language: en
Pages: 205
Authors: Cunyou Zhao
Categories: Science
Type: BOOK - Published: 2020-10-09 - Publisher: Frontiers Media SA

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Psychiatric diseases have a highly complex etiology, aggregating in families but not segregating in a traditional Mendelian manner. Recent approaches to underst
Genetics and Epigenetics of Psychiatric Diseases - Volume II
Language: en
Pages: 127
Authors: Cunyou Zhao
Categories: Science
Type: BOOK - Published: 2022-11-16 - Publisher: Frontiers Media SA

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Epigenetics in Psychiatry
Language: en
Pages: 846
Authors: Jacob Peedicayil
Categories: Medical
Type: BOOK - Published: 2021-08-25 - Publisher: Elsevier

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Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a d
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Language: en
Pages: 128
Authors: J. Bogousslavsky
Categories: Medical
Type: BOOK - Published: 2017-11-16 - Publisher: Karger Medical and Scientific Publishers

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After a period in which neurology and psychiatry have become more and more defined, neurologists' interest in psychiatric topics, and vice versa, has increased.
Epigenetics and Psychiatric Disease
Language: en
Pages: 450
Authors:
Categories: Science
Type: BOOK - Published: 2018-06-22 - Publisher: Academic Press

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Epigenetics and Psychiatric Disease, Volume 157, the latest volume in the Progress in Molecular Biology and Translational Science series, includes recent develo
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Language: en
Pages: 988
Authors: Charles B. Nemeroff, M.D., Ph.D.
Categories: Medical
Type: BOOK - Published: 2022-06-16 - Publisher: American Psychiatric Pub

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Language: en
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Authors: Raju Hajela
Categories: Self-Help
Type: BOOK - Published: 2015-09-10 - Publisher: FriesenPress

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Treating Addiction as a personal failing or weakness is stigmatizing and doesn’t work—not for those living with it, or for their loved ones. Understanding A
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Authors: Victor Corasolla Carregari
Categories: Electronic books
Type: BOOK - Published: 2022 - Publisher: Springer Nature

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This new volume, a part of the Proteomics, Metabolomics, Interactomics and Systems Biology series, will explain how proteomic studies of post-translational modi
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Language: en
Pages: 201
Authors: Gabriella Martino
Categories: Science
Type: BOOK - Published: 2020-11-04 - Publisher: Frontiers Media SA

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series:
The Molecular and Genetic Basis of Neurologic and Psychiatric Disease
Language: en
Pages: 930
Authors: Roger N. Rosenberg
Categories: Medical
Type: BOOK - Published: 2008 - Publisher: Lippincott Williams & Wilkins

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Completely updated for its Fourth Edition, this book is the most comprehensive, current review of the molecular and genetic basis of neurologic and psychiatric